Lipids And Blood Oxygen Transport

De Transcription | Bibliothèque patrimoniale numérique Mines ParisTech
Révision datée du 13 novembre 2025 à 09:34 par FlynnShattuck8 (discussion | contributions)
(diff) ← Version précédente | Voir la version actuelle (diff) | Version suivante → (diff)
Aller à : navigation, rechercher


One of the most fascinating observations and one among the only in vitro experiments that signifies these reverse results of sterols and fatty acids is their influence upon the oxidation processes in which pink cells intervene. When a sample of atypical venous blood is treated with a preparation of cholesterol or nonsaponifiable fractions, using the above talked about technique and after its separation from the cholesterol it's agitated with air or oxygen which is handed via these samples, the coloration becomes a shiny vermilion crimson, and this persists for a long time. When the identical venous blood is handled with a preparation of polyunsaturated fatty acids as talked about above, BloodVitals SPO2 the coloration becomes very dark, nearly black purple. When air or oxygen is passed by way of these samples, the blood turns into lighter in colour for less than a short while, the darker color reappearing inside a couple of minutes. One is immediately impressed by the similarity of the cholesterol treated blood to arterial blood, while the fatty acid treated blood is much like venous blood, and particularly to the color of venous blood in cases of shock.



We tried to tie in these findings with the observation of Binet regarding the changes in blood fatty acids when passing by the lungs. He has been in a position to indicate that the amount of the polyunsaturated members appears to be reduced by the passage of blood by way of the lungs. We could present that the crimson cells leaving the pulmonary vascular mattress are somewhat richer in the unbound cholesterol than they've been within the blood which entered the lungs. The lipid content is altered in an opposite method as the blood travels via the final circulation. That is, the polyunsaturated fatty acid content is elevated within the red cells whereas the amount of free cholesterol seems to be diminished. The sterol richer purple cells seem able to retaining for an extended time frame, the amount of oxygen which hemoglobin has mounted, BloodVitals review while a speedy discount of oxyhemoglobin is seen within the red cells when the polyunsaturated fatty acids intervene.



This led us to consider an intervention of those two groups of lipids in relation to the oxygen transportation by the red cells. Bearing in thoughts the truth that while cholesterol reduces cell permeability and polyunsaturated fatty acids increase it, an alternating intervention of those lipids appears to play a job in a greater distribution of oxygen. The oxygen which is fixed by hemoglobin when the red cells have passed the lungs, is basically retained as such by the intervention of the sterols till they reach the purpose in the tissues where liberation of oxygen is critical, this being favored now by the intervention of the fatty acids. The abnormally dark colour of the blood ensuing from its therapy in vitro with polyunsaturated fatty acids has recommended the intervention of such substances in those clinical situations during which similar color BloodVitals review modifications are noted within the blood as in shock. We are going to present our studies in shock under. For the second we'll only note that within the state of shock experimentally induced by trauma, burns or irradiation, or present in terminally in poor health adrenalectomized animals, BloodVitals SPO2 these animals have not only a excessive fatty acid content material, but that the form of fatty acids encountered are not the identical as in regular animals.



We have mentioned these abnormal fatty acids above. The present differences have been shown by measuring the quantity of oxalic acid that is produced when these fatty acids are submitted to a cautious standardized oxidative fission. The oxidative fission of the fatty acids not solely from their whole body however even from their blood has proven that for regular animals, no oxalic acid may very well be found, leading to the assumption that no conjugated fatty acids are current. On the other hand, oxalic acid appeared when fatty acids obtained from animals in shock or from their blood were broken down with the analytical methodology utilized. Of explicit significance for the pathogenic role of these fatty acids is the very fact which we are going to focus on once more under, that demise seems to ensue when the conjugation of fatty acids reaches a sure value, which is approximately the identical whether the animal has been traumatized, burned, irradiated or adrenalectomized, and impartial of the truth that death occurs in a short while or a number of days.